Use case 1 - Exploring the relationship between molecular interaction profiles and pharmacogenomics

Objective: Find the connection between drug response variability, protein interaction, and genetic association for a drug of interest (here warfarin).

How: We first search for "warfarin" in 'Drug search' page to obtain its ATC code (B01AA03). Next, we navigate to "B01AA03" and choose the “Network pharmacogenomics” tab.

Expected results:


Video: Watch the video guide here

Use case 2 - Comparing drug adverse reaction profiles of two similar ATC codes

Objective: Compare the adverse reactions of drugs in similar ATC codes. Here, we compare adverse reactions of drugs in ‘Non-selective monoamine reuptake inhibitors’ (ATC: N06AA) with those from ‘Selective serotonin reuptake inhibitors’ (ATC: N06AB). Both Anticholinergic agents and Dopaminergic agents fall under ‘Antidepressants’ (ATC: N06A).

How: Navigate to N06AA and select “Compare network adverse drug reactions” in “Network comparison” tab and add N06AB as a comparator.

Expected results: (This screenshot shows only a portion of the full results).


Video: Watch the video guide here

Use case 3 - Evaluate the overall impact of a variant

Objective: Find the predicted impact of a protein-coding genetic variant. Given a healthcare professional identifies a variant of interest in a patient, which has not been listed on drug labels for PGx-testing previously.

How: Navigating to the 'Variant search' page, enter the variant identifier (e.g. 9_35057179_T/C) in the search box.

Expected results: (This screenshot shows only a portion of the full results).

Table showing basic annotation and predicted variant effect scores of variant 9_35057179_T/C

Table showing Significant burden associations of variant 9_35057179_T/C

Video: Watch the video guide here